{"id":14,"date":"2021-09-29T21:13:28","date_gmt":"2021-09-29T21:13:28","guid":{"rendered":"https:\/\/paust.scripps.edu\/?page_id=14"},"modified":"2022-11-16T17:40:20","modified_gmt":"2022-11-16T17:40:20","slug":"paust-laboratory","status":"publish","type":"page","link":"https:\/\/paust.scripps.edu\/","title":{"rendered":""},"content":{"rendered":"

LATEST NEWS<\/h3>\t\t\t

2022<\/strong><\/p>\n

Dr. Paust\u2019s application\u00a0\u00a0R21 AI170555<\/strong>\u00a0is awarded by the National Institute of Health (NIH\/NIAID), titled: “Control of HIV-induced MDSC expansion and immunosuppression by cytotoxic lymphocytes.”<\/em><\/p>\n

Post-doctoral positions are available in the Paust lab as of January 2023:<\/p>\n

https:\/\/recruiting2.ultipro.com\/SCR1003TSRI\/JobBoard\/98759e7d-7ede-4c0b-ac7b-2c6293c7b522\/OpportunityDetail?opportunityId=dcea6353-1bf9-414f-9c8e-894ef8b9f1d7<\/a><\/p>\n

 <\/p>\n

2021<\/strong><\/p>\n

Dr. Paust\u2019s application R01 AI-161014 <\/strong>is awarded by the National Institute of Health (NIH\/NIAID), titled: \u201cHow antigen exposure shapes the subsequent NK cell response to HIV.\u201d<\/em><\/p>\n<\/div>\n\t\t<\/div><\/div><\/div><\/div><\/div>

RESEARCH<\/h3>\t\t\t

Members of the Paust laboratory are interested in the development and testing of novel immunotherapies that elicit clinically relevant Natural Killer cell-mediated anti-pathogen or anti-tumor immunity. Our research program is centered on the discovery that subsets of NK cells are long-lived and capable of antigen-speci\ufb01c immunological memory to viruses and altered self, giving precedence to investigations that seek to exploit NK cell activity to prevent or cure disease. Currently, we are pursuing three speci\ufb01c scienti\ufb01c goals: 1) Identi\ufb01cation of the mechanisms by which subsets of murine and human NK cells mediate antigen-speci\ufb01c immunological memory responses; 2) Identi\ufb01cation of NK cell-speci\ufb01c immune correlates of protection from infection or malignancy; 3) Development of effective, host-protective vaccine or therapeutic approaches that elicit potent NK cell-mediated recall responses in vivo. To enable our studies, we routinely utilize mouse models, xenograft models, and clinical samples for the immunological analyses of innate and adaptive NK cell-mediated immune responses.<\/p>\n<\/div>\n\t\t<\/div><\/div><\/div><\/div><\/div>

SILKE PAUST, PHD<\/h3>\t\t\t
<\/div>\n

Associate Professor<\/strong>
\nDepartment of Immunology and Microbiology<\/p>\n

Scripps Research Joint Appointments<\/strong>
\nAssociate Professor, Department of Immunology and Microbiology
\nFaculty, Graduate Program<\/p>\n

Other Joint Appointments
\n<\/strong>2018 –
\nMember, The San Diego Center for Precision Immunotherapy in the Moores Cancer Center, UC San Diego, San Diego, CA
\n2018 –
\nMember, Center for Aids Research, San Diego, CA<\/p>\n

Education
\n<\/strong>Ph.D., Immunology, Harvard University, 2005<\/p>\n

BIOSKETCH<\/a><\/p>\n<\/div>\n\t\t<\/div><\/div><\/div>

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